What should I tell my doctor before starting Detrol? What should I tell my doctor before starting DETROL? Following administration of a 5 mg oral dose of 14C-tolterodine solution to healthy volunteers, 77% of radioactivity was recovered in urine and 17% was recovered in feces in 7 days. What should I tell my doctor before starting tolterodine tartrate extended-release capsules? Stiripentol: May increase the serum concentration of CYP3A4 Substrates. Management: Use of stiripentol with CYP3A4 substrates that are considered to have a narrow therapeutic index should be avoided due to the increased risk for adverse effects and toxicity. Any CYP3A4 substrate used with stiripentol requires closer monitoring.
To treat incontinence, doctors inject botulinum toxin into the bladder muscle. This is done with a needle that is inserted via a long tube called a cystoscope that goes up into the bladder. The extended release formulation should be swallowed whole. Taking a road trip? Mirabegron may increase your blood pressure or make your blood pressure worse if you have a history of high blood pressure. Your doctor will check your blood pressure while you are taking mirabegron. Tell your doctor if you experience severe or persistent headache or dizziness. Tolterodine Tartrate Tablets are indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.
Acetylcholinesterase Inhibitors: May diminish the therapeutic effect of Anticholinergic Agents. Anticholinergic Agents may diminish the therapeutic effect of Acetylcholinesterase Inhibitors. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using tolterodine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain problems , slow heartbeat, QT prolongation in the family history of certain heart problems QT prolongation in the EKG, sudden cardiac death.
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Both frequency and volume decreases are important. The effect of 200 mg daily dose of ketoconazole on the pharmacokinetics of tolterodine immediate-release was studied in 8 healthy volunteers, all of whom were poor metabolizers see for discussion of poor metabolizers. Tolterodine tartrate extended-release capsules may cause allergic reactions that may be serious. Symptoms of a serious allergic reaction may include swelling of the face, lips, throat, or tongue. If you experience these symptoms, you should stop taking tolterodine tartrate extended-release capsules and get emergency medical help right away.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you're still frustrated by overactive bladder or other continence problems that won't let up or go away, you might want to learn more about other OAB treatment options. Or it could signal a health problem. It is soluble in methanol, slightly soluble in ethanol, and practically insoluble in toluene. Ask your healthcare professional how you should dispose of any medicine you do not use. What should I tell my doctor before starting Tolterodine Tartrate Tablets? Teratogenic effects were observed in some animal reproduction studies.
Kane says, "because for the most part, a number of them basically have about the same effectiveness, but they have different patterns of side effects. There has been no association of Torsade de Pointes in the international post-marketing experience with Tolterodine Tartrate Tablets or tolterodine tartrate extended-release capsules. Limit and alcohol intake. It is not known whether this drug passes into milk. Discuss the risks and benefits with your doctor before -feeding. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Know the medicines you take. Tolteridinhydrochlorid PH: Ph. Eur. Urethral insert: A thin, flexible solid tube in the urethra that blocks the flow of leaking urine. Medicines like tolterodine tartrate extended-release capsules can cause blurred vision, dizziness, and drowsiness.
DETROL LA may cause allergic reactions that may be serious. Patient Information Leaflet to each patient. In healthy volunteers, coadministration of tolterodine immediate-release 4 mg 2 mg bid for 7 days and a single dose of warfarin 25 mg on day 4 had no effect on prothrombin time, Factor VII suppression, or on the pharmacokinetics of warfarin. Patients should be informed that antimuscarinic agents such as tolterodine tartrate extended-release capsules may produce the following effects: blurred vision, dizziness, or drowsiness. Patients should be advised to exercise caution in decisions to engage in potentially dangerous activities until the drug's effects have been determined. These are not all the side effects with Detrol. For a complete list, ask your doctor or pharmacist. F. Protect from light. Do not drive, operate machinery, or do other dangerous activities until you know how tolterodine tartrate extended-release capsules affect you. If you have not noticed any effect by then, talk to your doctor. The recommended dose for patients with mild to moderate hepatic impairment Child-Pugh Class A or B is tolterodine tartrate extended-release capsules, 2 mg once daily. Because these spontaneously reported events are from the worldwide postmarketing experience, the frequency of events and the role of tolterodine in their causation cannot be reliably determined. Michel MC. Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome. Expert Opin Pharmacother. Neurological Tests. Diagnostic tests and procedures that help the doctor confirm or rule out the presence of a nerve disorder. The difference between DETROL LA and placebo was statistically significant. No mutagenic effects of tolterodine were detected in a battery of in vitro tests, including bacterial mutation assays Ames test in 4 strains of Salmonella typhimurium and in 2 strains of Escherichia coli, a gene mutation assay in L5178Y mouse lymphoma cells, and chromosomal aberration tests in human lymphocytes. Tolterodine was also negative in vivo in the bone marrow micronucleus test in the mouse. The active substance in Detrusitol is tolterodine.
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine. Goldfrank LR, Lewin NA, Flomenbaum NE et al. Psychotropics. Antidepressants: tricyclics, tetracyclics, monoamine oxidase inhibitors, and others. In: Goldfrank LR, Flomenbaum NE, Lewin NA et al, eds. Use with caution. The effects may be increased because of slower removal of the medicine from the body. Like all medicines, Detrusitol can cause side effects, although not everybody gets them. In that case, omit the forgotten dose and follow the normal dose schedule. Nocturia means you have to get up a lot during the night to go to the bathroom. Both urinary contraction and salivation are mediated via cholinergic muscarinic receptors.
Food may increase oral bioavailability of conventional tablets; however, such changes are not expected to be clinically important. 1 Food does not appear to alter the pharmacokinetics of extended-release capsules. 23 See Administration under Dosage and Administration. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Store at room temperature away from moisture and heat. What happens if I miss a dose? No overall differences in safety were observed between the older and younger patients treated with tolterodine. Teva Pharmaceuticals USA, Inc. Keep it in a dry place. Sixty-six percent of patients receiving Tolterodine Tartrate Tablets 2 mg bid reported adverse events versus 56% of placebo patients. LA based on AUC of tolterodine and its 5-HMT metabolite. QTcF and a population-specific QTcP method were used to correct QT interval for heart rate. No single QT correction method is known to be more valid than others. QT interval was measured manually and by machine, and data from both are presented. Tolterodine tartrate extended-release capsules did not help the symptoms of overactive bladder when studied in children. Pharmacokinetic studies revealed that tolterodine is metabolized at a slower rate in poor metabolizers than in extensive metabolizers; this results in significantly higher serum concentrations of tolterodine and in negligible concentrations of 5-HMT. Who should not take DETROL? The remainder of the population is referred to as "extensive metabolizers.
The effect of tolterodine on QT interval prolongation has been found to correlate with tolterodine plasma concentrations. The QTc interval increase appears to be greater in CYP2D6 poor metabolizers than extensive metabolizers. These observations should be considered in clinical decisions to prescribe tolterodine for patients who are taking class IA or class III antiarrhythmic agents. For the treatment of overactive bladder with symptoms of urinary frequency, urgency, and urge urinary incontinence. Elimination half-life of tolterodine prolonged in patients with hepatic impairment. 1 10 See Hepatic Impairment under Dosage and Administration. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Colucci VJ, Rivey MP. Tolterodine-warfarin drug interaction. Ann Pharmacother. Several different medications have been approved to relieve the symptoms of urinary frequency and urgency. Store Detrol at room temperature, between 59 and 86 degrees F 15 and 30 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Detrol out of the reach of children and away from pets. The first step in treatment will be to try some things at home, such as urinating at scheduled times. This leaflet summarizes the most important information about Tolterodine Tartrate Tablets. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about Tolterodine Tartrate Tablets that is written for health professionals. You can also call 1-877-446-3679 1-877-4-INFO-RX. Use and dose must be determined by your doctor. The benefit of the treatment should be re-evaluated after 2 or 3 months. Distribution of tolterodine not fully characterized. 17 18 Tolterodine and its 5-hydroxymethyl metabolite do not appear to distribute extensively into erythrocytes.
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Metabolism for discussion of poor metabolizers. Patricia Goode, MD, a professor of medicine in the Center for Aging at the University of Alabama at Birmingham. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure. Do you drink alcohol or caffeinated beverages?
At first, 2 milligrams mg two times a day. Your doctor may adjust your dose if needed. DETROL is right for you. Detrusitol. Another strength 1mg is also available.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Abrams P, Freeman R, Anderstróm C et al. Tolterodine, a new antimuscarinic agent: as effective but better tolerated than oxybutynin in patients with an overactive bladder. Br J Urol. Those side effects are not new, however. They had been noted in previous studies. The adverse events are reported regardless of causality.
Tolterodine has a pronounced effect on bladder function. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness; chest pain; confusion; difficult or painful urination; disorientation; fainting; fast or irregular heartbeat; hallucinations; memory problems; severe dizziness; swelling of the hands, ankles, or feet. This can increase capacity in the bladder and lessen contractions. Botox is only recommended for people who can't control symptoms with behavioral therapies or oral medications.